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. 2019 Oct 22;10:1280. doi: 10.3389/fphys.2019.01280

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Copyright © 2019 Bacqué-Cazenave, Fossat, Issa, Edwards, Delbecque and Cattaert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of 5-HT cell stimulation on Dep MNs persists in high-divalent cation solution. (A) High-divalent cation solution raises the threshold for spikes. The effect of high-divalent cation solution was tested on unitary EPSPs recorded from a Dep MN. In control situation, the CBCO unit (black trace) evoked an EPSP in the intracellularly recorded Dep MN (green trace) in which very few polysynaptic events occurred. After 10 min of perfusion of 5-HT (10 μM) in the bathing medium, the polysynaptic pathways were activated (see the numerous and variable events present in the decay phase of the monosynaptic EPSP). If the 5-HT was applied while the preparation was perfused with high-divalent cation solution, no polysynaptic event occurred (dark blue traces). (B) Persistence of a depolarizing response induced by 5-HT cell stimulation in high-divalent cation solution. (C) Persistence of a hyperpolarizing response induced by 5-HT cell stimulation in high-divalent cation solution. Note that this Dep MN was producing pacemaker properties, the frequency of which decreased during 5-HT cell stimulation.