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. 2019 Oct 22;10:1123. doi: 10.3389/fneur.2019.01123

Figure 2.

Figure 2

Molecular mechanisms of vesicular synergy. The role of different types of vesicular glutamate transporters (VGLUTS) in different brain regions in drug addiction. In the ventral tegmental area (VTA), VGLUT2 participates in the cooperative release of glutamate from dopaminergic neurons. In the nucleus accumbens (NAc), VGLUT2, and VGLUT3 participate in the cooperative release of glutamate from GABAergic neurons. VGLUT3 participates in the cooperative release of glutamate from cholinergic neurons. In the prefrontal cortex (PFC), VGLUT1 participates in the cooperative release of glutamatergic neurons. In the hippocampus (Hip), VGLUT1, and VGLUT2 participate in the cooperative release of glutamate from CA1 and CA3 neurons.