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. 2019 Oct 22;10:709. doi: 10.3389/fendo.2019.00709

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Copyright © 2019 Couvineau, Voisin, Nicole, Gratio, Abad and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Beneficial actions of the orexins in immune mediated disorders. Orexin neuropeptides are known to efficiently regulate sleep and arousal states, appetite and feeding, gastrointestinal motility, metabolism, cognitive processes. More recently, considering the synergic and dynamic cross-talk between the nervous and immune systems, they also display potent neuroprotective and immunoregulatory features. Therefore, the orexin/receptors system may be consider as a potential therapeutical tool for the treatment of: (1) acute inflammatory-induced diseases such as septic shock, (2) chronic inflammatory inflammatory-induced diseases such as inflammatory bowl diseases (IBD) or cancer, and (3) immune-mediated neurodegenerative diseases of the central nervous system such as high fat diet (HFD)-induced obesity, Alzheimer's disease, narcolepsy (T1N), or multiple sclerosis.