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. 2019 Sep 9;20:25–41. doi: 10.1016/j.isci.2019.09.005

Figure 7.

Figure 7

Decreased Seizure Threshold in Lgl1+/− Mice and Rescue of Social Interaction by NMDAR Blockade

(A) Quantification of the occurrence of jerking/jumping, Straub tail, and clonic-tonic seizures in Lgl1+/+ and Lgl1+/− animals following 50 mg/kg PTZ administration. Fisher's exact test.

(B) Quantification of the latency to the first observation of behaviors following 50 mg/kg PTZ administration. N = 17 Lgl1+/+, 15 Lgl1+/− animals. Mann-Whitney U statistic test.

(C) Representative heatmaps during the social interaction phase of the social interaction test following intraperitoneal injection with 50 μL saline, 30 mg/kg ketamine, 0.3 mg/kg MK-801, or 20 mg/kg memantine. White asterisk denotes location of the novel mouse.

(D and E) (D) Quantification of time spent in social (S) or nonsocial (NS) regions of interest and (E) interaction preference of treated animals. N = (saline) 17 Lgl1+/+, 19 Lgl1+/− animals; (ketamine) 14 Lgl1+/+, 17 Lgl1+/− animals; (MK-801) 13 Lgl1+/+, 14 Lgl1+/− animals; (memantine) 19 Lgl1+/+, 17 Lgl1+/− animals.

*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.