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. 2019 Sep 9;20:1–13. doi: 10.1016/j.isci.2019.09.003

Figure 1.

Figure 1

Body Weight Gain of Orexin Receptor-Deficient Mice Fed Chow or High-Fat Diet (HFD)

(A) Body weights of wild-type (n = 33), orexin KO (n = 32), Ox1r KO (n = 23), and Ox2r KO mice (n = 22) at the age of 3 weeks. One-way ANOVA followed by Tukey's test.

(B–E) Body weight measured at the age of 9 weeks (B) and weight gain from 3 weeks of age (C). Weight gain was measured weekly for chow (D) and HFD (E) mice groups. Wild-type (chow n = 12, HFD n = 21), orexin KO (chow n = 13, HFD n = 19), Ox1r KO (chow n = 10, HFD n = 13) and Ox2r KO mice (chow n = 9, HFD n = 13).

(F) At the age of 9 weeks, showing the body lengths of wild-type (chow n = 9, HFD n = 11), orexin KO (chow n = 9, HFD n = 8), Ox1r KO (chow n = 10, HFD n = 13), and Ox2r KO mice (chow n = 9, HFD n = 13).

(G) The BMI of wild-type at the age of 9 weeks. Wild-type (chow n = 13, HFD n = 11), orexin KO (chow n = 9, HFD n = 8), Ox1r KO (chow n = 10, HFD n = 13), and Ox2r KO mice (chow n = 9, HFD n = 13).

(H) The serum leptin levels in wild-type (chow n = 8, HFD n = 10), orexin KO (chow n = 8, HFD n = 10), Ox1r KO (chow n = 8, HFD n = 7), and Ox2r KO mice (chow n = 8, HFD n = 9).

Two-way ANOVA followed by Tukey's test. *p < 0.05, **p < 0.01, ***p < 0.001 among genotypes. #p < 0.05, ##p < 0.01, ###p < 0.001 between diet groups. All data are presented as mean ± SEM. See also Figure S1.