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. 2019 Sep 9;20:1–13. doi: 10.1016/j.isci.2019.09.003

Figure 2.

Figure 2

Energy Metabolism of Orexin Receptor-Deficient Mice Fed Chow or High-Fat Diet (HFD)

(A) Daily food intake during 11–13 weeks of age in wild-type (chow n = 8, HFD n = 6), orexin KO (chow n = 7, HFD n = 7), Ox1r KO (chow n = 8, HFD n = 6), and Ox2r KO mice (chow n = 8, HFD n = 7) at the ages of 11–13 weeks.

(B–D) The energy expenditure (B), respiratory quotient (C), and oxygen consumption (D) at the ages of 11–13 weeks. The mice were fed a chow or HFD from the age of 3 weeks. Wild-type (chow n = 12, HFD n = 7), orexin KO (chow n = 10, HFD n = 8), Ox1r KO (chow n = 7, HFD n = 6), and Ox2r KO mice (chow n = 16, HFD n = 8).

Two-way ANOVA followed by Tukey's test for each diet group. *p < 0.05, **p < 0.01, ***p < 0.001. Compared with the chow diet, #p < 0.05, ##p < 0.01, ###p < 0.001. Data are presented as mean ± SEM.