Glucose Metabolism of Orexin Receptor-Deficient Mice Fed Chow or High-Fat Diet (HFD)
(A) The blood glucose levels of wild-type (chow n = 12, HFD n = 7), orexin KO (chow n = 12, HFD n = 8), Ox1r KO (chow n = 10, HFD n = 7), and Ox2r KO mice (chow n = 9, HFD n = 13) at the age of 9 weeks.
(B) The serum insulin levels in wild-type (chow n = 8, HFD n = 10), orexin KO (chow n = 8, HFD n = 10), Ox1r KO (chow n = 8, HFD n = 7), and Ox2r KO mice (chow n = 10, HFD n = 9).
Two-way ANOVA followed by Tukey's test for each diet group. *p < 0.05, ***p < 0.001. Compared with the chow diet, ##p < 0.01, ###p < 0.001. Data are presented as mean ± SEM.