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. 2019 Sep 9;20:1–13. doi: 10.1016/j.isci.2019.09.003

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© 2019 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of Exercise and a High-Fat Diet on the Body Weight Growth of Orexin Neuron-Ablated Mice

(A) Male wild-type mice. Chow without a wheel (n = 12), high-fat diet (HFD) without a wheel (n = 11), chow with a wheel (n = 7), HFD with a wheel (n = 12).

(B) Male orexin-ataxin3 mice. Chow without a wheel (n = 10), HFD without a wheel (n = 9), chow with a wheel (n = 8), HFD with a wheel (n = 7).

(C) Female wild-type mice. Chow without a wheel (n = 20), HFD without a wheel (n = 10), chow with a wheel (n = 9), HFD with a wheel (n = 10).

(D) Female orexin-ataxin3 mice. Chow without a wheel (n = 7), HFD without a wheel (n = 8), chow with a wheel (n = 8), HFD with a wheel (n = 6).

For (A)–(D) body weight was measured weekly from the ages of 4 to 15 weeks. Mice were fed normal chow or a high-fat diet and housed in a cage equipped with or without a running wheel. Two-way ANOVA followed by a comparison of the main effect after Bonferroni adjustment. *p < 0.05, **p < 0.01, ***p < 0.001. Data are presented as mean ± SEM.