Table 2.
Genotype frequencies for 7 TMCO1 SNPs and association with POAG
| SNP | Genotypes alleles |
Cases (%) | Controls (%) | Hardy- Weinberg |
Age and sex adjusted OR (95% CI) |
P value |
| rs11430311 | InsT/insT | 925 (60.3) | 938 (59.8) | 0.99 | Reference | 0.76 |
| InsT/WT | 533 (34.8) | 546 (34.8) | 0.99 (0.84 to 1.17) | |||
| WT/WT | 75 (4.9) | 84 (5.4) | 0.88 (0.62 to 1.25) | |||
| InsT | 2383 (77.7) | 2422 (77.2) | Reference | 0.60 | ||
| WT | 683 (22.3) | 714 (22.8) | 0.97 (0.85 to 1.10) | |||
| rs4657473 | CC | 1251 (81.4) | 1272 (81.0) | 0.02 | Reference | <0.001 |
| CT | 275 (17.9) | 265 (16.9) | 1.05 (0.86 to 1.29) | |||
| TT | 10 (0.7) | 33 (2.1) | 0.20 (0.09 to 0.42) | |||
| C | 2777 (90.4) | 2809 (89.5) | Reference | 0.08 | ||
| T | 295 (9.6) | 331 (10.5) | 0.85 (0.71 to 1.02) | |||
| rs4657474 | GG | 926 (60.3) | 941 (59.9) | 0.76 | Reference | 0.81 |
| GA | 537 (35.0) | 549 (35.0) | 1.00 (0.85 to 1.18) | |||
| AA | 73 (4.8) | 80 (5.1) | 0.89 (0.62 to 1.27) | |||
| G | 2389 (77.8) | 2431 (77.4) | Reference | 0.70 | ||
| A | 683 (22.2) | 709 (22.6) | 0.97 (0.86 to 1.11) | |||
| rs4657475 | CC | 926 (60.3) | 941 (60.0) | 0.65 | Reference | 0.81 |
| CT | 538 (35.0) | 549 (35.0) | 1.00 (0.85 to 1.18) | |||
| TT | 72 (4.7) | 79 (5.0) | 0.89 (0.62 to 1.28) | |||
| C | 2390 (77.8) | 2431 (77.5) | Reference | 0.72 | ||
| T | 682 (22.2) | 707 (22.5) | 0.98 (0.86 to 1.11) | |||
| rs116461237 | GG | 1492 (97.2) | 1527 (97.3) | 0.60 | Reference | 0.68 |
| GA | 43 (2.8) | 41 (2.6) | 1.03 (0.64 to 1.64) | |||
| AA | 0 (0.0) | 1 (0.1) | N/A | |||
| G | 3027 (98.6) | 3095 (98.6) | Reference | 0.98 | ||
| A | 43 (1.4) | 43 (1.4) | 0.99 (0.63 to 1.57) | |||
| rs61058666 | GG | 1336 (87.0) | 1355 (86.4) | 0.47 | Reference | 0.95 |
| GC | 192 (12.5) | 209 (13.3) | 1.01 (0.81 to 1.27) | |||
| CC | 7 (0.5) | 5 (0.3) | 1.21 (0.34 to 4.27) | |||
| G | 2864 (93.3) | 2919 (93.0) | Reference | 0.84 | ||
| C | 206 (6.7) | 219 (7.0) | 1.02 (0.82 to 1.27) | |||
| rs4656461 | AA | 925 (60.3) | 940 (59.9) | 0.65 | Reference | 0.81 |
| AG | 538 (35.0) | 549 (35.0) | 1.01 (0.86 to 1.18) | |||
| GG | 72 (4.7) | 79 (5.0) | 0.89 (0.62 to 1.28) | |||
| A | 2388 (77.8) | 2429 (77.5) | Reference | 0.75 | ||
| G | 682 (22.2) | 707 (22.5) | 0.78 (0.86 to 1.11) |
*P values for any difference between three genotypes, and linear difference by number of alleles, respectively.
POAG, primary open-angle glaucoma; SNP, single nucleotide polymorphism.