Figure 1.
The combined Manhattan plots for significant associations with inflammatory markers studied in (A) Northern Finland Birth Cohort 1966 and in (B) meta-analyses with three other Finnish population cohorts. Significance threshold p<3.1×10−9 derives from the standard p value limit for genome-wide significance p<5×10−8 corrected for 16 markers examined in the present study. Novel association signals are highlighted with red font and replicated loci are marked with black font. sE-selectin, soluble E-selectin; IL1b, interleukin 1-beta; IP10, interferon gamma-induced protein 10; MCP1, monocyte chemoattractant protein 1; sICAM-1, soluble intercellular adhesion molecule-1; sVCAM-1, soluble vascular cell adhesion molecule-1; TNFa, tumour necrosis factor alpha; VEGF, vascular endothelial growth factor.