Table 2.

Significant loci associating with the circulating inflammatory phenotypes

Study	Marker	Locus	Chr:Position	Candidate gene	Nearest gene(s)	Annotation	dbSNP reference	INFO	EA	EAF	Beta	P value	HetPVal	Variance explained	Total variance explained
NFBC1966	sE-selectin	9q34.2	9:136 141 870	ABO	ABO	Intronic	rs2519093	0.994	T	0.188	−0.903	4.48e-305	NA	0.249	0.258
		11q24.2	11:126 266 665	ST3GAL4	ST3GAL4	Intronic	rs11220471	0.967	G	0.212	−0.162	7.72e-12	NA	0.009
	sICAM-1	9q34.2	9:136 141 870	ABO	ABO	Intronic	rs2519093	0.994	T	0.188	−0.352	7.43e-48	NA	0.038	0.118
		19p13.2	19:10 383 403	ICAM1	ICAM1	Intronic	rs117960796	0.802	A	0.012	−1.669	8.03e-40	NA	0.066
		19p13.2	19:10 497 360	ICAM1	CDC37	Intergenic	rs74428614	0.992	A	0.163	0.226	1.14e-16*	NA	0.014
	sVCAM-1	9q34.2	9:136 131 322	ABO	ABO	Missense	rs8176746	1.000	T	0.129	0.256	5.06e-19	NA	0.015	0.038
		12q23.3	12:104 448 391	HSP90B1	GLT8D2	Intronic	rs117238625	0.981	A	0.023	0.510	2.90e-14	NA	0.012
		17q24.2	17:66 823 805	ABCA8	ABCA8	Intergenic	rs112001035	0.883	A	0.060	−0.324	1.04e-13	NA	0.012
Meta-analyses	IL1β	6p22.1	6:30 017 071		HLA locus	Intronic	rs6917603	1.000	C	0.251	−0.163	1.76e-12	1.00	0.010	0.015
		6p22.1	6:30 013 887		HLA locus	Intronic	rs9261224	1.000	T	0.035	0.261	1.31e-09 *	1.00	0.005
	IP10	4q21.1	4:76 899 176	CXCL10	SAD1	Intronic	rs192716315	0.851	C	0.003	1.513	2.71e-13	1.00	0.014	0.014
	MCP1	1q23.2	1:159 175 354	ACKR1	ACKR1	Missense	rs12075	1.000	A	0.469	0.148	1.43e-33	1.51e-13	0.011	0.011
	TNFα	13q14.3	13:51 141 997	DLEU1	DLEU1	Intronic	rs17074575	0.803	G	0.002	2.131	2.71e-09	1.00	0.018	0.018
	VEGF	4p16.2	4:5 636 073	STK32B	EVC2	Intronic	rs186725382	0.875	A	0.001	−2.380	4.53e-10	1.00	0.011	0.052
		6p21.1	6:43 927 050	VEGFA	C6orf223	Intergenic	rs7767396	1.000	A	0.523	0.284	8.35e-105	1.22e-69	0.040	0.056
		9p24.2	9:2 686 273	VLDLR	VLDLR, KCNV2	Intergenic	rs7030781	0.959	T	0.373	-0.099	1.57e-13	5.34e-04	0.005

Statistical significance is considered at p<3.1×10⁻⁹. Novel findings are highlighted with bold font. All positions correspond to human genome build 37.

*Indicates associations that are significant after conditioning the analyses on the locus-specific lead variant on the preceding row.

EA, effect allele; EAF, effect allele frequency; HLA, human leukocyte antigen; HetPVal, p value of heterogeneity as estimated by Cochrane’s Q-test; IL1β, interleukin 1-beta; INFO, imputation score in NFBC1966; IP10, interferon gamma-induced protein 10; MCP1, monocyte chemoattractant protein 1; NA, not available; NA, not available; NFBC1966, Northern Finland Birth Cohort 1966; TNFα, tumour necrosis factor alpha; VEGF, vascular endothelial growth factor; dbSNP, single nucleotide polymorphism database; sE-selectin, soluble E-selectin; sICAM-1, soluble intercellular adhesion molecule -1; sVCAM-1, soluble vascular cell adhesion molecule-1.