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. 2019 Oct 21;6(5):ENEURO.0089-19.2019. doi: 10.1523/ENEURO.0089-19.2019

Figure 11.

Figure 11.

Effect of STN stimulation pattern on performance by levodopa-treated 6-OHDA rats in the skilled forelimb reaching test. Error bars indicate mean ± SE. Patterns not sharing the same letter are significantly different from each other (p < 0.05). See Table 1 for n for each pattern. A, Total number of trials per experimental session as a function of stimulation pattern and drug condition. One-way matched pairs t test performed on 6-OHDA-treated animal baseline performance without stimulation or levodopa (n = 3) versus with levodopa (n = 3) found a significant effect of drug (p = 0.026). One-way RMANOVA performed levodopa-treated 6-OHDA animal performance found no significant effect of stimulation pattern (p = 0.92). B, Percentage of trials resulting in pellet dispensation as a function of stimulation pattern and drug condition. One-way matched pairs t test performed on 6-OHDA-treated animal baseline performance without stimulation or levodopa (n = 3) versus with levodopa (n = 3) found a significant effect of drug (p = 0.016). One-way RMANOVA performed on levodopa-treated 6-OHDA animal performance found no significant effect of stimulation pattern (p = 0.58). C, Minimum interpress interval as a function of stimulation pattern and drug condition. One-way matched pairs t test performed on 6-OHDA-treated animal baseline performance without stimulation or levodopa (n = 3) versus with levodopa (n = 3) found no significant effect of drug (p = 0.24). One-way RMANOVA performed on levodopa-treated 6-OHDA animal performance found no significant effect of stimulation pattern (p = 0.42). D, Initiation to hit peak latency as a function of stimulation pattern and drug condition. One-way matched pairs t test performed on 6-OHDA-treated animal baseline performance without stimulation or levodopa (n = 3) versus with levodopa (n = 3) found no significant effect of drug (p = 0.16). One-way RMANOVA performed on levodopa-treated 6-OHDA animal performance found no significant effect of stimulation pattern (p = 0.36). E, Mean press duration as a function of stimulation pattern and drug condition. One-way matched pairs t test performed on 6-OHDA-treated animal baseline performance without stimulation or levodopa (n = 3) versus with levodopa (n = 3) found no significant effect of drug (p = 0.15). One-way RMANOVA performed on levodopa-treated 6-OHDA animal performance found no significant effect of stimulation pattern (p = 0.44).