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. 2019 Oct 22;10:2493. doi: 10.3389/fimmu.2019.02493

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Copyright © 2019 Almeida, Couceiro, López-Sejas, Alves, Růžičková, Tarazona, Solana, Freitas-Tavares, Santos-Rosa and Rodrigues-Santos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of NKT-like cell profiles in treated CML according to TKI generation and deep molecular response. NKT-like cells from CML patients had different patterns of receptor expression associated with function/activation (CD107a, IFN-γ, HLA-DR, and CD69), tumor recognition (NKp30, NKp44, NKp46, and NKp80) and immune regulation (TIM-3, LAG-3, CD137). Second generation TKIs were associated with remarkably activation status (CD69) and downregulation of NKp44 and NKp80. Patients in deep molecular response were associated with downregulation of NKp44 and LAG-3. Top (in red) of the diagram represents upregulation of receptors and the bottom (in green) represent the downregulation of receptors by NKT-like cells.