FIG 7.

HNRNPK promoter analysis shows conserved SREBP1 binding sites. (A) Schematic diagram of human HNRNPK gene loci showing the localization of miR-7. The active promoter of the HNRNPK region correlates with CpG islands (green) and enriched H3K4Me3 histone marks. ChIP-assayed transcription factors shown include SP1, SREBP1, and SREBP2 (highlighted in red). Data were compiled using the UCSC Genome Browser (NCBI36/hg18; http://genome.ucsc.edu). (B) Sequence alignment of the human and mouse HNRNPK promoters (minus strand) showing the localization of predicted Sp1 (orange, 85% confidence; purple, 90% confidence), E-box (green), and NFY (blue) binding sites found using Consite (http://consite.genereg.net/cgi-bin/consite) and Genomatix (http://www.genomatix.de). Transcription start sites (TSS) are highlighted in red. Genomic locations for human (NCBI36/hg18) and mouse (NCBI37/mm9) are provided at the top. scaRNA, small cajal RNAs; snoRNA, small nucleolar RNAs.