Table 2.
Mean cytokine and growth factor concentrations in the vitreous from baseline to week 4.
| Molecular factor levels, pg/ml | Baseline | Week 2 | P* | Week 3 | P* | Week 4 | P* | P trend |
|---|---|---|---|---|---|---|---|---|
| IL-6 | 0.39 ± 0.25 | 0.59 ± 0.24 | 0.38 | 0.67 ± 0.23 | 0.32 | 0.72 ± 0.57 | 0.06 | 0.008 |
| IL-8 | 0.53 ± 0.25 | 1.46 ± 0.48 | 0.04 | 11.5 ± 17.0 | 0.22 | 2.6 ± 3.1 | 0.03 | <0.001 |
| IL-1β | 0.20 ± 0.05 | 0.24 ± 0.06 | 0.58 | 0.46 ± 0.13 | 0.11 | 0.37 ± 1.90 | 0.12 | 0.13 |
| TNF-β | 2.1 ± 0.79 | 3.23 ± 1.05 | 0.47 | 3.59 ± 0.54 | 0.29 | 0.37 ± 0.13 | 0.12 | 0.71 |
| GM-CSF | 0.29 ± 0.05 | 0.33 ± 0.06 | 1.00 | 0.39 ± 0.03 | 0.29 | 0.29 ± 0.07 | 0.89 | 0.75 |
| IFN-γ | 3.8 ± 1.77 | 5.07 ± 1.53 | 1.00 | 9.28 ± 1.20 | 0.29 | 6.08 ± 2.65 | 0.14 | 0.21 |
| CRP | 13.0 ± 13.1 | 30.7 ± 12.1 | 0.22 | 35.9 ± 9.8 | 0.07 | 34.8 ± 12.0 | 0.0008 | 0.001 |
| PlGF | 5.3 ± 3.8 | 9.0 ± 3.8 | 0.66 | 13.2 ± 5.2 | 0.05 | 11.2 ± 7.7 | 0.02 | 0.02 |
| PDGF-BB | 6.2 ± 10.1 | 26.2 ± 8.4 | 0.32 | 50.4 ± 19.0 | 0.0009 | 34.6 ± 27.4 | 0.002 | 0.001 |
| VEGF | 215.1 ± 145.5 | 311.9 ± 188.0 | 0.58 | 1875.5 ± 1356.8 | 0.11 | 1251.5 ± 1876.0 | 0.13 | 0.02 |
| Ang2 | 13617.0 ± 8170.2 | 106464.6 ± 57182.56 | 0.18 | 24064.2 ± 10409.9 | 0.47 | 38593.8 ± 8313.4 | 0.02 | 0.007 |
*compared to baseline
Abbreviations:
IL-6, interleukin 6; IL-8, interleukin 8; IL-1β, interleukin 1 beta; TNF-β, tumor necrosis factor beta; GM-CSF, granulocyte macrophage colony stimulating factor; IFN-γ, interferon gamma; CRP, C reactive protein; PlGF, placental growth factor; PDGF-BB, platelet derived growth factor BB; VEGF, vascular endothelial growth factor; Ang2, angiopoietin 2.