Table 4.
Multivariable analysis of survival including pre‐ and post‐therapeutically available clinical factors in the resected non‐CTx cohort
| HR | 95% CI | P value* | |
|---|---|---|---|
| Pre‐therapeutic factors† | |||
| Clinical tumour stage | |||
| cT2 | 1 | – | <0.001 |
| cT3/4 | 2.74 | 1.84–4.07 | |
| Age | 1.03 | 1.01–1.05 | 0.001 |
| Molecular classification | 0.027 | ||
| MSS/EBV(−) | 1 | – | – |
| EBV(+) | 0.20 | 0.03–1.46 | 0.113 |
| MSI‐L | 1.53 | 0.83–2.84 | 0.175 |
| MSI‐H | 0.55 | 0.30–1.00 | 0.049 |
| Post‐therapeutic factors‡ | |||
| pN | |||
| pN0 | 1 | – | <0.001 |
| pN1 | 3.15 | 1.95–5.10 | |
| Age | 1.03 | 1.01–1.04 | 0.004 |
| Resection status | |||
| R0 | 1 | – | 0.020 |
| R1 | 1.68 | 1.08–2.60 | |
| Localisation | 0.026 | ||
| Proximal | 1 | – | – |
| Middle | 0.67 | 0.42–1.05 | 0.079 |
| Distal | 0.52 | 0.33–0.83 | 0.006 |
| Total | 1.09 | 0.51–2.31 | 0.830 |
| Post‐therapeutic factors (R0 resected, non‐CTx cohort) | |||
| pN | |||
| pN0 | 1 | – | <0.001 |
| pN1 | 2.67 | 1.59–4.48 | |
| Age | 1.03 | 1.01–1.05 | 0.004 |
| Molecular classification | 0.035 | ||
| MSS/EBV(−) | 1 | – | – |
| EBV(+) | 0.23 | 0.03–1.66 | 0.144 |
| MSI‐L | 1.80 | 0.88–3.71 | 0.110 |
| MSI‐H | 0.55 | 0.28–1.10 | 0.090 |
| pT§ | |||
| pT1/2 | 1 | – | 0.023 |
| pT3/4 | 1.36 | 1.04–1.78 | |
*
P value of forward likelihood ratio Cox's regression model.
†
Pre‐therapeutic factors included: age, sex, localisation, Laurén subtypes, clinical tumour stage, molecular classification.
‡
Post‐therapeutic factors included: age, sex, localisation, Laurén subtypes, pT, pN, M‐status, R‐status, molecular classification.
§
Classification according to 7th Edition UICC 2007.