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. 2019 Oct 28;9:15435. doi: 10.1038/s41598-019-51894-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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shRNA screening data after applying a strict cut-off. (A) shRNA screening data were filtered by establishing three criteria: mean ratio higher than 1 (Log Ratio >1) compared to the uninfected control, standard error lower than 2 (SE <2) and a consistency higher than 60%. (B) Out of 2,888 genes, twenty-nine host genes were selected for further validation. High effect in the shRNA screening after MRSA infection and/or a biological relevance for intracellular pathogenesis were used as criteria to choose the most interesting hits. Selected genes are highlighted in red.