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. 2019 Oct 28;9:15385. doi: 10.1038/s41598-019-51673-0

Table 2.

Proteins that exhibited significant differences in concentrations between obese and lean groups in plasma and/or serum.

Protein Plasma Serum
Lean Obese Obese vs lean log2 ratio H-B Adj. p value FDR Adj. p value Lean Obese Obese vs lean log2 ratio H-B Adj. p value FDR Adj. p value
NPX (mean ± SEM) NPX (mean ± SEM)
4E-BP1 6.57 ± 0.21 7.54 ± 0.10 0.97 ns 0.0106 4.57 ± 0.10 6.18 ± 0.33 1.62 ns 0.0081
ADAM-TS13 5.17 ± 0.06 4.94 ± 0.04 −0.22 ns ns 6.38 ± 0.05 6.19 ± 0.03 −0.18 ns 0.0336
ADM 6.33 ± 0.06 7.11 ± 0.09 0.78 0.0002 0.0001 6.03 ± 0.08 6.82 ± 0.11 0.79 0.0032 0.0004
AGRP 3.64 ± 0.11 3.12 ± 0.07 −0.52 ns 0.0136 3.74 ± 0.13 3.10 ± 0.08 −0.64 ns 0.0081
AMBP 5.52 ± 0.02 5.72 ± 0.04 0.20 ns 0.0037 5.53 ± 0.05 5.78 ± 0.03 0.26 ns 0.0058
CCL3 (CVD II) 3.18 ± 0.04 3.67 ± 0.05 0.49 0.0002 0.0001 3.65 ± 0.07 4.13 ± 0.07 0.48 0.0241 0.0018
CCL4 6.04 ± 0.07 6.67 ± 0.13 0.63 ns 0.0095 7.33 ± 0.12 7.76 ± 0.19 0.43 ns ns
CCL18 5.28 ± 0.22 6.09 ± 0.19 0.81 ns ns 5.36 ± 0.21 6.25 ± 0.18 0.89 ns 0.0259
CCL19 8.98 ± 0.15 9.66 ± 0.13 0.68 ns 0.0246 9.16 ± 0.15 9.82 ± 0.12 0.66 ns 0.0222
CDCP1 1.56 ± 0.14 2.16 ± 0.17 0.60 ns ns 1.64 ± 0.14 2.37 ± 0.18 0.73 ns 0.0274
CES1 1.41 ± 0.05 2.04 ± 0.20 0.63 ns ns 1.31 ± 0.04 2.02 ± 0.16 0.71 ns 0.0136
CHI3L1 5.27 ± 0.21 6.21 ± 0.27 0.94 ns ns 5.60 ± 0.13 6.61 ± 0.27 1.01 ns 0.0266
CHL1 2.47 ± 0.09 2.14 ± 0.04 −0.33 ns 0.0406 2.64 ± 0.12 2.20 ± 0.05 −0.43 ns 0.0366
CSF-1 7.03 ± 0.06 7.30 ± 0.07 0.27 ns ns 7.13 ± 0.05 7.43 ± 0.08 0.30 ns 0.0349
CSTB 3.65 ± 0.14 4.27 ± 0.12 0.62 ns 0.0321 3.65 ± 0.13 4.54 ± 0.21 0.89 ns 0.0155
CTSD 3.76 ± 0.09 4.61 ± 0.11 0.85 0.0025 0.0003 4.14 ± 0.05 4.94 ± 0.14 0.79 0.0400 0.0026
CTSZ 3.81 ± 0.13 4.33 ± 0.12 0.52 ns ns 3.98 ± 0.06 4.46 ± 0.14 0.47 ns 0.0373
CXCL10 8.82 ± 0.17 9.51 ± 0.15 0.69 ns ns 8.70 ± 0.18 9.59 ± 0.15 0.89 ns 0.0127
CXCL11 6.36 ± 0.16 6.96 ± 0.18 0.60 ns ns 6.87 ± 0.16 7.94 ± 0.26 1.07 ns 0.0213
ENG 1.47 ± 0.07 1.40 ± 0.06 −0.07 ns ns 1.54 ± 0.05 1.31 ± 0.03 −0.23 ns 0.0183
FABP4 3.65 ± 0.30 5.57 ± 0.15 1.93 0.0115 0.0010 3.78 ± 0.26 5.72 ± 0.16 1.93 0.0024 0.0004
FCN2 4.48 ± 0.16 5.22 ± 0.10 0.74 ns 0.0106 4.04 ± 0.14 4.87 ± 0.10 0.83 0.0422 0.0026
FGF-21 (CVD II) 4.56 ± 0.43 7.12 ± 0.48 2.56 ns 0.0105 4.54 ± 0.43 7.03 ± 0.48 2.49 ns 0.0105
FGF-21 (I) 3.50 ± 0.41 5.98 ± 0.44 2.48 ns 0.0086 3.59 ± 0.40 6.03 ± 0.44 2.44 ns 0.0081
Gal-9 6.96 ± 0.04 7.51 ± 0.07 0.55 0.0019 0.0003 7.07 ± 0.06 7.64 ± 0.08 0.57 0.0045 0.0005
GH 9.51 ± 0.69 6.38 ± 0.66 −3.13 ns 0.0318 9.63 ± 0.69 6.46 ± 0.64 −3.17 ns 0.0222
GLO1 3.29 ± 0.10 3.78 ± 0.18 0.49 ns ns 4.66 ± 0.17 5.56 ± 0.25 0.90 ns 0.0415
HAOX1 2.90 ± 0.30 4.71 ± 0.41 1.80 ns 0.0220 2.97 ± 0.31 4.81 ± 0.42 1.84 ns 0.0183
HB-EGF 3.84 ± 0.09 3.94 ± 0.08 0.10 ns ns 5.32 ± 0.13 6.52 ± 0.16 1.20 0.0030 0.0004
HGF 6.76 ± 0.07 7.62 ± 0.14 0.86 0.0249 0.0019 7.58 ± 0.09 8.60 ± 0.14 1.02 0.0026 0.0004
IGFBP-1 3.85 ± 0.20 1.47 ± 0.26 −2.38 0.0002 0.0001 3.98 ± 0.18 1.55 ± 0.27 −2.44 0.0002 0.0002
IGFBP-2 6.65 ± 0.25 5.81 ± 0.12 −0.85 ns ns 6.84 ± 0.21 5.95 ± 0.11 −0.89 ns 0.0146
IL-1ra 5.33 ± 0.09 7.05 ± 0.21 1.72 0.0013 0.0003 5.80 ± 0.10 7.47 ± 0.20 1.67 0.0009 0.0004
IL-6 2.36 ± 0.17 4.17 ± 0.34 1.81 ns 0.0044 2.46 ± 0.16 4.22 ± 0.33 1.75 ns 0.0043
IL-10RB 6.34 ± 0.09 6.70 ± 0.08 0.36 ns 0.0473 6.53 ± 0.08 6.94 ± 0.08 0.41 ns 0.0146
IL-18 7.75 ± 0.14 8.47 ± 0.20 0.72 ns ns 7.88 ± 0.15 8.67 ± 0.22 0.79 ns 0.0396
IL-18R1 6.61 ± 0.11 7.16 ± 0.13 0.55 ns 0.0360 6.80 ± 0.09 7.37 ± 0.13 0.57 ns 0.0188
KIT 3.31 ± 0.08 2.84 ± 0.09 −0.47 ns 0.0095 3.29 ± 0.08 2.99 ± 0.10 −0.30 ns ns
LAP TGF-β−1 5.64 ± 0.11 6.01 ± 0.08 0.38 ns ns 6.94 ± 0.09 7.28 ± 0.08 0.34 ns 0.0417
LEP 4.06 ± 0.32 6.66 ± 0.11 2.60 0.0019 0.0003 4.09 ± 0.34 6.81 ± 0.11 2.72 0.0018 0.0004
LILRB2 2.18 ± 0.09 2.62 ± 0.08 0.44 ns 0.0225 2.11 ± 0.11 2.68 ± 0.08 0.58 ns 0.0083
LTBR 1.75 ± 0.12 2.02 ± 0.08 0.27 ns ns 1.84 ± 0.03 2.10 ± 0.05 0.26 ns 0.0043
MCP-1 9.35 ± 0.07 9.87 ± 0.05 0.52 0.0058 0.0005 10.52 ± 0.13 11.02 ± 0.13 0.51 ns ns
MCP-3 1.39 ± 0.00 1.48 ± 0.04 0.09 ns ns 1.42 ± 0.02 2.07 ± 0.10 0.65 0.0254 0.0018
MCP-4 2.19 ± 0.16 2.72 ± 0.12 0.53 ns ns 3.56 ± 0.17 4.36 ± 0.22 0.80 ns 0.0450
MIP-1 alpha (I) 3.35 ± 0.03 3.83 ± 0.06 0.48 0.0027 0.0003 3.72 ± 0.07 4.28 ± 0.08 0.56 0.0107 0.0009
MPO 2.30 ± 0.23 2.91 ± 0.08 0.61 ns ns 2.92 ± 0.13 3.52 ± 0.12 0.59 ns 0.0222
NCAM1 2.27 ± 0.09 1.89 ± 0.06 −0.38 ns 0.0191 2.26 ± 0.10 1.90 ± 0.08 −0.36 ns ns
NEMO 3.40 ± 0.17 3.76 ± 0.22 0.36 ns ns 1.58 ± 0.04 2.27 ± 0.18 0.69 ns 0.0223
OSM 2.40 ± 0.12 3.39 ± 0.21 1.00 ns 0.0106 3.95 ± 0.16 5.14 ± 0.29 1.19 ns 0.0208
PAI-1 3.49 ± 0.31 5.80 ± 0.23 2.31 0.0030 0.0003 7.21 ± 0.09 7.60 ± 0.07 0.39 ns 0.0274
PLC 5.00 ± 0.14 5.45 ± 0.07 0.45 ns ns 5.23 ± 0.06 5.61 ± 0.03 0.38 0.0064 0.0006
PON3 5.45 ± 0.26 4.29 ± 0.27 −1.17 ns 0.0406 5.43 ± 0.21 4.22 ± 0.26 −1.22 ns 0.0146
PRCP 0.78 ± 0.07 1.11 ± 0.06 0.33 ns 0.0231 0.68 ± 0.05 1.11 ± 0.06 0.43 0.0067 0.0006
PRSS8 8.75 ± 0.08 9.20 ± 0.08 0.45 ns 0.0106 8.93 ± 0.09 9.43 ± 0.08 0.50 ns 0.0073
RARRES2 9.60 ± 0.13 10.22 ± 0.07 0.62 ns 0.0106 9.97 ± 0.09 10.44 ± 0.05 0.48 ns 0.0036
SCGB3A2 2.12 ± 0.26 0.96 ± 0.12 −1.15 ns 0.0130 2.23 ± 0.26 0.98 ± 0.13 −1.25 ns 0.0081
SELE 2.10 ± 0.13 2.81 ± 0.12 0.70 ns 0.0095 2.26 ± 0.12 2.93 ± 0.14 0.67 ns 0.0146
SPON2 9.78 ± 0.04 10.01 ± 0.04 0.24 ns 0.0036 10.31 ± 0.05 10.54 ± 0.03 0.23 ns 0.0105
STAMPB 3.16 ± 0.12 3.56 ± 0.15 0.41 ns ns 1.84 ± 0.04 2.38 ± 0.16 0.54 ns 0.0450
t-PA 4.06 ± 0.20 5.23 ± 0.09 1.17 0.0276 0.0019 4.28 ± 0.24 5.89 ± 0.09 1.61 0.0082 0.0007
TGM2 6.03 ± 0.13 6.35 ± 0.08 0.32 ns ns 3.85 ± 0.08 4.66 ± 0.17 0.81 ns 0.0082
TNF-R1 4.69 ± 0.14 5.27 ± 0.06 0.58 ns 0.0220 5.01 ± 0.06 5.53 ± 0.06 0.52 0.0019 0.0004
TNF-R2 3.24 ± 0.13 3.64 ± 0.04 0.41 ns ns 3.42 ± 0.07 3.77 ± 0.07 0.35 ns 0.0146
TNFRSF10A 2.06 ± 0.05 2.27 ± 0.07 0.22 ns ns 2.13 ± 0.07 2.42 ± 0.07 0.29 ns 0.0462
TNFRSF11A 4.04 ± 0.09 4.60 ± 0.08 0.56 ns 0.0036 4.40 ± 0.12 4.94 ± 0.08 0.54 ns 0.0146
TNFSF14 2.96 ± 0.08 3.73 ± 0.08 0.77 0.0004 0.0001 4.23 ± 0.12 4.97 ± 0.19 0.74 ns 0.0274
TR-AP 3.40 ± 0.14 3.89 ± 0.08 0.49 ns ns 3.54 ± 0.14 4.12 ± 0.10 0.58 ns 0.0266
TRAIL-R2 4.40 ± 0.09 4.66 ± 0.05 0.26 ns ns 4.59 ± 0.09 4.89 ± 0.05 0.30 ns 0.0481
TRAIL 7.25 ± 0.09 7.61 ± 0.08 0.36 ns ns 7.49 ± 0.09 7.92 ± 0.09 0.43 ns 0.0213
U-PAR 3.28 ± 0.15 3.64 ± 0.06 0.36 ns ns 3.78 ± 0.07 4.26 ± 0.10 0.48 ns 0.0104
VEGF-A 9.19 ± 0.06 9.58 ± 0.05 0.40 0.0196 0.0016 9.85 ± 0.13 10.40 ± 0.09 0.55 ns 0.0213
vWF 3.18 ± 0.18 3.55 ± 0.11 0.37 ns ns 6.21 ± 0.15 6.95 ± 0.18 0.73 ns 0.0349

Differences in mean normalized protein expression (NPX) values between obese and lean groups are reported as a log2 ratio. p values were adjusted for multiple comparisons using either Holm-Bonferroni (H-B) or false discovery rate (FDR); ns, not significant (adj. p > 0.05). For proteins that are present in duplicate protein panels, the panel is indicated in parentheses: I, inflammation; CVII, cardiovascular II; and CVIII, cardiovascular III.