Figure 1.

Overall conduct of experiment. (A) For the first part of the experiment, 18 NSG mice were fed oral TA to induce liver cirrhosis. TA was administered, and 6 mice were sacrificed at 4 months, 6 months and 10 months respectively. They were compared to 18 control NSG mice, each given normal drinking water for the same duration. (B) For the second part of the experiment, NSG mice were given 4 months of oral TA. They were then subsequently transplanted with intrasplenic HFH, and given a further 2 months of TA, for a total duration of 6 months of TA. These mice were sacrificed at 6 months for analysis. They were compared to sham transplant mice given oral TA for 4 months, intrasplenic phosphate buffered saline (PBS), and a further 2 months of oral TA.