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. 2019 Oct 28;9:15400. doi: 10.1038/s41598-019-51066-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) DDR1 expression showed significant inverse correlation with methylation status in patients. Data from TCGA for two representative CpGs in the DDR1 promoter (cg02680487 and cg02695062) in LUAD and LUSC. (B,C) Kaplan Meier curves in patients from the CURELUNG cohort showing continuous survival analysis. Significantly lower DFS in patients with low DDR1 methylation levels (green color), in comparison with patients with high methylation levels (red) was found. (D,E) Survival analyses in the CUN-HGUV cohort analyzed by pyrosequencing. Kaplan Meier curves showed that, levels below the median significantly predicted reduced DFS (D). In the case of OS (E), the trend was the same but results were not statistically significant.