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. Author manuscript; available in PMC: 2019 Oct 29.
Published in final edited form as: Cell Rep. 2019 Sep 17;28(12):3105–3119.e7. doi: 10.1016/j.celrep.2019.08.036

Figure 4. miR-21 Downregulates Target mRNAs in Tumor-Associated Microglia.

Figure 4.

(A) In unsupervised clustering analysis, the top 750 most differentially expressed genes microglia clustered on the basis of tumor status and EV-GFP uptake status.

(B) MA-plot shows 441 significantly upregulated and 359 downregulated genes (plotted in red) when comparing EV-GFPpos with EV-GFPneg microglia.

(C) Heatmap shows relative gene expression for 59 validated miR-21 gene targets. Bold gene names indicate genes with p-adj < 0.05 in differential expression analysis EV-GFPpos versus EV-GFPneg microglia.