Table 2.

CSF biomarkers in iNPH compared with non-iNPH disorders, cognitive disorders and movement disorders

	iNPH	Non-iNPH disorders	Cognitive disorders	Movement disorders
	n=82	n=297	n=144	n=153
T-tau (pg/mL)	245 (131)	496 (443)***	725 (517)***	282 (186)
P-tau (pg/mL)	32 (12)	54 (36)***	72 (38)***	37 (22)*
NFL (pg/mL)	1717 (1963)	1960 (2508)	2340 (3147)	1603 (1633)
Aβ38 (pg/mL)	1526 (519)	2194 (794)***	2360 (757)***	2037 (798)***
Aβ40 (pg/mL)	3800 (1193)	5428 (1684)***	5889 (1610)***	4994 (1641)***
Aβ42 (pg/mL)	364 (138)	454 (197)***	387 (182)	517 (190)***
sAPPα (pg/mL)	446 (178)	693 (282)***	726 (299)***	661 (262)***
sAPPβ (pg/mL)	321 (121)	498 (188)***	527 (193)***	471 (179)***
MCP-1 (pg/mL)	492 (109)	416 (138)***	442 (132)*	391 (138)***

CSF biomarkers in iNPH compared to non-iNPH disorders, cognitive disorders and movement disorders. Concentrations are given as mean and SD. Significance testing was done by one-way ANCOVA corrected for age and sex with Dunnett’s multiple comparisons test and is shown as *p< 0.05, **p< 0.01, ***p<0.001.

Aβ, AD-related amyloid β; AD, Alzheimer’s disease; ANCOVA, analysis of covariance; CBD, corticobasal degeneration; CSF, cerebrospinal fluid; Cognitive disorders, AD+FTLD+VAD; FTLD, frontotemporal lobe degeneration; MCP-1, monocyte chemoattractant protein 1; MSA, multiple system atrophy; Movement disorders, PD, MSA, PSP, CBD; NFL, neurofilament light; Non-iNPH disorders, AD+FTLD+VAD+PD+MSA+PSP+CBD; PD, Parkinson’s disease; PSP, progressive supranuclear palsy; P-tau, phosphorylated tau; T-tau, total tau; VAD, vascular dementia; iNPH, idiopathic normal pressure hydrocephalus; sAPP, soluble amyloid precursor protein.