Table 3.
Characteristics of the 4378 Patients With Intracranial Aneurysms
| Variables for 4378 IA Patients From 1980 to 2015 | 125 Fusiform IA Patients Including 22 fIA Patients With Concomitant sIAs | 450 First Degree Relatives to the fIA Patients | 340 Matched Controls to the fIA Patients | 4253 Saccular IA Patients With No fIAs | 17 825 First Degree Relatives to the sIA Patients | 12 669 Matched Controls to the sIA Patients | P Value—Total fIA Vs Total sIAa | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Unruptured fIA n=93 (64%) | Ruptured fIA n=32 (26%) | Total fIA n=125 | 0 fIA 1 sIA | 0 fIA 1 sIA | Unruptured sIA n=1330 (31%) | Ruptured sIA n=2923 (69%) | Total sIA n=4253 | 0 fIA 224 sIA (76 aSAH) | 0 fIA 58 sIA (33 aSAH) | <0.0005 | |
| Median age at IA diagnosis, y (25 and 75 percentiles) | 66 (57 to 72) | 59 (48 to 73) | 64 (55 to 72) | 47 at sIA | 75 at sIA | 57 (48 to 66) | 52 (43 to 62) | 54 (45 to 63) | 47 (42 to 54) at sIA | 56 (52 to 73) at sIA | <0.0005 |
| Presentation | |||||||||||
| Incidental | 64 (69%) | … | … | … | … | 1164 (88%) | … | … | … | … | <0.0005 |
| Symptomatic | 29 (31%) | 54 (4%) | |||||||||
| sIA family screening | … | 112 (8%) | |||||||||
| Women, n (%) | 39 (42%) | 21 (66%) | 60 (48%) | 222 (49%) | 160 (47%) | 754 (57%) | 1598 (55%) | 2352 (55%) | 8706 (49%) | 7029 (55%) | 0.106 |
| sIA family, n (%) | 5 (5%) | 2 (6%) | 7 (5.7%) | … | … | 259 (20%) | 314 (11%) | 573 (14%) | … | … | 0.007 |
| Concomitant sIA, n (%) | … | … | 22 sIA (18%) | … | … | … | … | … | … | … | |
| Multiple fIAs (≥2), n (%) | 7 (8%) | 1 (3%) | 8 (6%) | … | … | … | … | … | … | … | |
| Multiple sIAs (≥2), n (%) | 9 (10%) | 0 (0%) | 9 (7%) | … | … | 380 (29%) | 811 (28%) | 1191 (28%) | … | … | |
| AAA total | 9 (10%) | … | 9 (7%) | 2 (0.4%) | 4 (0.6%) | 24 (2%) | 13 (0.4%) | 37 (1%) | 35 (0.2%) | 54 (0.4%) | <0.0005 |
| Ruptured | 2 (2%) | 2 (2%) | … | … | 2 (0.2%) | 6 (0.2%) | 8 (0.2%) | 11 (0.1%) | 12 (0.1%) | ||
| Confirmed TAA total | 1 (1%) | … | 1 (1%) | 2 (0.4%) | … | 8 (0.6%) | 2 (0.1%) | 10 (0.2%) | 12 (0.1%) | 10 (0.1%) | 0.273 |
| Ruptured | … | … | … | … | … | … | 4 (0.0%) | 1 (0.0%) | |||
| Suspected TAA | 3 (4%) | 1 (3%) | 4 (4%) | … | … | … | … | … | … | … | |
| AAA + TAA total | 3 (3%) | … | 3 (2%) | … | … | … | … | … | 2 (0.0%) | 1 (0.0%) | |
| Ruptured | 1 (1%) | 1 (1%) | … | … | |||||||
| Unspecified AA | … | … | … | … | … | … | … | 1 (0.0%) | 10 (0.1%) | 3 (0.0%) | |
| Dissection | 1 (1%) | … | 1 (1%) | 2 (0.4%) | … | … | 2 (0.1%) | 2 (0.0%) | 5 (0.0%) | 18 (0.1%) | 0.08 |
| AA or dissection | 17 (18%) | 1 (3%) | 18 (14%) | 6 (1%) | 4 (1%) | 27 (2%) | 16 (0.1%) | 50 (1%) | 64 (0.4%) | 86 (0.7%) | <0.0005 |
| Ruptured | 3 (3%) | … | 3 (2%) | … | … | 2 (0.0%) | 5 (0.0%) | 8 (0.0%) | 15 (0.1%) | 13 (0.1%) | |
| Median age at AA diagnosis, y (25 and 75 percentiles) | … | … | 63 (58 to 73) | 50 (46 to 54) | 76 (73 to 81) | … | … | 65 (59 to 73) | 66 (58 to 72) | 70 (63 to 76) | 0.61 |
| Comorbid diseases in IA patients from 1995 to 2014 | n=69 | n=20 | n=89 | n=405 | n=251 | n=1142 | n=1580 | n=2722 | n=15 652 | n=10 391 | |
| ADPKD, n (%) | 1 (1%) | 1 (3%) | 2 (2%) | 0 | 0 | 19 (1%) | 32 (1%) | 51 (1%) | 33 (0.2%) | 7 (0.1%) | 0.663 |
| Marfan, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 (0.0%) | 1 (0.0%) | |
| Loeys‐Dietz, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ehlers‐Danlos, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Hypertension, n (%) | 63 (91%) | 18 (90%) | 81 (91%) | 146 (45%) | 245 (97%) | 921 (81%) | 1123 (71%) | 2044 (75%) | 8780 (56%) | 7989 (77%) | 0.001 |
| Type 2 diabetes mellitus, n (%) | 15 (22%) | 5 (25%) | 20 (22%) | 34 (8%) | 61 (24%) | 174 (15%) | 187 (12%) | 361 (13%) | 2270 (14%) | 1742 (17%) | 0.012 |
| Atherosclerotic disease or hyperlipidemia | 23 (25%) | 3 (9%) | 37 (30%) | 98 (24%) | 172 (68%) | 187 (16%) | 158 (10%) | 345 (13%) | 5764 (37%) | 5132 (49%) | <0.0005 |
AA indicates aortic aneurysm; AAA, abdominal aortic aneurysm; ADPKD, autosomal dominant polycystic kidney disease; aSAH, aneurysmal subarachnoid haemorrhage; fIA, fusiform intracranial aneurysm; IA, intracranial aneurysm; sIA saccular intracranial aneurysm; TAA, thoracic aortic aneurysm.
a
Statistical significance calculated for the difference of the total fIA and sIA groups.