. 2019 Oct 2;8(20):e012138. doi: 10.1161/JAHA.119.012138

Table 4.

Effect of High Salt Diet and Monoclonal Anti‐Marinobufagenin 3E9 Antibody on Extracellular Matrix and Transcription Factors in the Left Ventricle of Dahl‐S Rats Following 8 Weeks of Dietary Intervention Combined With 1 Week of Anti‐Marinobufagenin mAb Treatment (Pair Analysis of Gene Expression by Microarray)

Gene	Description	Z‐Ratio
Gene	Description	HSC/LSC	HSAB/HSC
Ctgf	Connective tissue growth factor	2.04^*	−4.10^*, ^‡
Tgfb1	Transforming growth factor‐β1	1.72^*	−1.82^*, ^‡
Tgfb2	Transforming growth factor‐β2	2.57^†	−3.9^†, ^‡
MAPK3	Mitogen‐activated protein kinase 3	1.64^*	−3.17^†, ^‡
Sparc	Secreted acidic cysteine rich glycoprotein/osteonectin	2.08^†	−1.64^*, ^‡

Values are expressed as the Z‐ratio of gene expression at termination (week 8) of the experiment. Dahl‐S indicates Dahl salt‐sensitive; AB, marinobufagenin antibody.

*P<0.05, ^† P<0.01, changes in Z‐ratio within pairs.

P<0.05, high salt (HS) with anti‐marinobufagenin antibody (AB) (HSAB)/high salt control (HSC) vs HSC/low salt control (LSC) by unpaired t test; n=6 per group.