Table 3.
Predictors of Post‐Blanking Atrial Arrhythmia Relapse After an Ablation Procedure
| Variable | Univariate Cox Regression | Multivariate Cox Regression—1 | Multivariate Cox Regression—2 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Age (per y) | 1.01 | 1.00 to 1.02 | 0.008 | … | … | … | 1.00 | 0.99 to 1.01 | 0.441 |
| Female sex | 1.20 | 1.02 to 1.41 | 0.024 | … | … | … | 1.07 | 0.89 to 1.29 | 0.454 |
| AF duration (per y) | 1.03 | 1.02 to 1.04 | <0.001 | 1.03 | 1.02 to 1.04 | <0.001 | 1.02 | 1.01 to 1.03 | 0.001 |
| Paroxysmal AF | 0.52 | 0.45 to 0.60 | <0.001 | 0.53 | 0.46 to 0.61 | <0.001 | 0.54 | 0.45 to 0.66 | <0.001 |
| Congestive heart failure | 1.58 | 1.24 to 2.00 | <0.001 | … | … | … | … | … | … |
| Hypertension | 1.23 | 1.06 to 1.43 | 0.007 | … | … | … | … | … | … |
| Diabetes mellitus | 1.44 | 1.14 to 1.81 | 0.002 | 1.33 | 1.05 to 1.67 | 0.016 | 1.36 | 1.03 to 1.78 | 0.027 |
| Stroke or TIA | 1.31 | 1.00 to 1.61 | 0.051 | … | … | … | … | … | … |
| Vascular disease | 1.19 | 0.94 to 1.53 | 0.155 | … | … | … | … | … | … |
| Obstructive sleep apnea | 1.48 | 1.15 to 1.91 | 0.003 | 1.32 | 1.03 to 1.69 | 0.028 | 1.21 | 0.92 to 1.58 | 0.176 |
| CHA2DS2‐VASc | 1.13 | 1.07 to 1.19 | <0.001 | … | … | … | … | … | … |
| BMI (per kg/m2) | 1.01 | 1.00 to 1.01 | 0.044 | 1.01 | 1.00 to 1.02 | 0.017 | 1.03 | 1.01 to 1.05 | 0.001 |
| eGFR (per mL/min) | 0.99 | 0.99 to 1.00 | 0.073 | … | … | … | … | … | … |
| Indexed LA volume (per mL/m2) | 1.01 | 1.01 to 1.02 | <0.001 | … | … | … | 1.01 | 1.00 to 1.01 | 0.002 |
| LVEF (per %) | 0.99 | 0.98 to 0.99 | 0.002 | … | … | … | 1.00 | 0.99 to 1.01 | 0.773 |
| Cryoballoon ablation | 0.92 | 0.78 to 1.08 | 0.293 | … | … | … | … | … | … |
| Class I or III ADDs on discharge | 1.59 | 1.37 to 1.85 | <0.001 | … | … | … | 1.24 | 1.02 to 1.51 | 0.030 |
| Center case‐load (per 100 ablations/y) | 0.94 | 0.91 to 0.97 | <0.001 | 0.94 | 0.91 to 0.97 | <0.001 | 1.28 | 1.09 to 1.50 | 0.003 |
Model 2 was created using the previously identified predictors, with additional adjustment for age, sex, left ventricular ejection fraction, left atrium volume, and use of anti‐arrhythmic drugs on discharge. AAD indicates anti‐arrhythmic drugs; AF, atrial fibrillation; BMI, body mass index; CHA2DS2‐VASc, cardiac failure or dysfunction, hypertension, age ≥75 years [doubled], diabetes mellitus, stroke [doubled]‐vascular disease, age 65 to 74 years, sex category [female]; HR, hazard ratio; LA, left atrium; LVEF, left ventricular ejection fraction; TIA, transitory ischemic attack.