Table 4.

Sub‐Analyses for Anticoagulation and Ablation Energy in Obese Patients

	RF (n=502)	Cryoballoon (n=190)	P Value
Overweight patients (BMI >30 kg/m2)
All complications	4.6% (23)	7.9% (15)	0.090
Cardiac tamponade	1.0% (5)	0.5% (1)	0.552
Stroke	0.2% (1)	0.5% (1)	0.474
Phrenic nerve palsy	0.4% (2)	4.2% (8)	<0.001
Vascular complications	1.6% (8)	2.6% (5)	0.369
Other bleeds	0.2% (1)	0% (0)	0.538
Bradyarrhythmic complications	0.2% (1)	0% (0)	0.538
Gastroparesis	0.2% (1)	0% (0)	0.538
Transient myocardial stunning	0.2% (1)	0% (0)	0.538
Acute pulmonary edema	0.2% (1)	0% (0)	0.538

	NOAC (n=180)	VKA (n=512)	P Value
Overweight patients (BMI >30 kg/m2)
Stroke	0% (0)	0.4% (2)	0.401
TIA	0% (0)	0% (0)	N.A.
Systemic embolism	0% (0)	0% (0)	N.A.
Cardiac tamponade	0.6% (1)	1.0% (5)	0.600
Vascular complications	1.7% (3)	2.0% (10)	0.808
Other bleeds	0% (0)	0.2% (1)	0.538

	NOAC (n=61)	VKA (n=123)	P Value
Patients with BMI >35 kg/m2
Stroke	0% (0)	0% (0)	N.A.
TIA	0% (0)	0% (0)	N.A.
Systemic embolism	0% (0)	0% (0)	N.A.
Cardiac tamponade	0% (0)	1.6% (2)	0.317
Vascular complications	1.6% (1)	0% (0)	0.154
Other bleeds	0% (0)	0% (0)	N.A.

	NOAC (n=13)	VKA (n=26)	P Value
Patients with BMI >40 kg/m2
Stroke	0% (0)	0% (0)	N.A.
TIA	0% (0)	0% (0)	N.A.
Systemic embolism	0% (0)	0% (0)	N.A.
Cardiac tamponade	0% (0)	3.8% (1)	0.474
Vascular complications	0% (0)	0% (0)	N.A.
Other bleeds	0% (0)	0% (0)	N.A.

	NOAC (n=23)	VKA (n=36)	P Value
Patients weighting >120 kg
Stroke	0% (0)	0% (0)	N.A.
TIA	0% (0)	0% (0)	N.A.
Systemic embolism	0% (0)	0% (0)	N.A.
Cardiac tamponade	0% (0)	0% (0)	N.A.
Vascular complications	0% (0)	0% (0)	N.A.
Other bleeds	0% (0)	0% (0)	N.A.

BMI indicates body mass index; NOAC, novel oral anticoagulants; RF, radio frequency; TIA, transient ischemic attack; VKA, vitamin K antagonists.