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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Diabetologia. 2019 Jul 4;62(8):1319–1328. doi: 10.1007/s00125-019-4928-8

Fig. 1.

Fig. 1

HbA1c levels and 95% confidence interval bands, measured annually over time in DPP/DPPOS in all participants based on original intention-to-treat assignments (red, placebo; green, intensive lifestyle intervention; blue, metformin). The colored area surrounding each line represents the 95% CI. The differences in the mean HbA1c over time for intensive lifestyle intervention vs placebo, and metformin vs placebo, were significant (p<0.001). The dashed lines reflect the HbA1c levels currently used by the American Diabetes Association to define ‘prediabetes’ (5.7–6.4% [39–46 mmol/mol]) and diabetes (≥6.5% [48 mmol/mol]). Values in mmol/mol on the right-hand y-axis are converted from the % values on the left and rounded up or down. This figure is available as a downloadable slide.