Table 2. Clinical characteristics and AMR results of BI completely decline, BI moderately decline, and lack of BI decline cases of leprosy.
| Clinical characteristics | BI completely declines N (%) | BI moderately decline N (%) | Lack of BI decline N (%) | p-value |
|---|---|---|---|---|
| Gender | p = 0.833 | |||
| Male | 57 (26.1) | 75 (34.5) | 23 (10.6) | |
| Female | 24 (11) | 28 (12.8) | 11 (5) | |
| WHO Classification | ||||
| MB | 66 (30.2) | 103 (47.3) | 33 (15.1) | p = 0.000 |
| PB | 15 (6.9) | 0 (0) | 1 (0.5) | |
| Initial BI* | 1.08 (0–4.8.0) | 3.82(1.2.–5.7) | 2.65 (0–5.8.0) | p = 0.000 |
| BI at RFT* | 0.21 (0–3.6) | 2.50 (0.4–4.8) | 3.45 (1–5.8.0) | p = 0.855 |
| BI at 1 year post RFT* | 0 (0) | 2.04 (0.2–4.3) | 3.45 (1–5.8.0) | p = 0.000 |
| 16S rRNA PCR | ||||
| Positive | 81 (100) | 103 (100) | 34 (100) | p = 0.000 |
| Negative | 0 | 0 | 0 | |
| AMR mutations | ||||
| folP1 | 1 (0.5) | 5 (2.2) | 0 | p = 0.268 |
| folP1+ gyrA | 0 (0) | 0 (0) | 0 | |
| rpoB + gyrA | 0 (0) | 1 (0.5) | 0 | |
| rpoC | 1 (0.5) | 0 (0) | 0 | |
| gyrA + 23S rRNA | 0 | 0 (0) | 0 | |
| gyrA | 1 (0.5) | 0 (0) | 3 (1.4) | |
| gyrB | 0 (0) | 0 (0) | 1 (0.5) | |
| 23S rRNA | 0 (0) | 1 (0.5) | 0 |
Complete, moderate, and lack of BI decline criteria were calculated by evaluating initial BI and BI at 1-year post-RFT. MB-multibacillary, PB-paucibacillary. *Values represented in mean (range), BI-bacillary index, RFT-released from treatment, N (%)-number (percentage), AMR-anti microbial resistance.