Figure 3.

HMs in the promoters are predictive for the differentiation potential of the neural progenitors

A. Alluvial plots showing the dynamics of H3K9ac and H3K27me3 in the genome. Regions having no H3K9ac or H3K27m3 found are labeled as unmarked, whereas regions with both H3K9ac and H3K27me3 found as labeled as both. B. ROC curves of H3K9ac and H3K27me3 in the promoter regions as predictors of gene activity using the top 1500 highly expressed genes as actual positives (top panels) and the bottom 1500 lowly expressed genes as actual positives (bottom panels). Unsupervised hierarchical clustering of normalized H3K9ac (C) and H3K27me3 (D) signals in the promoter regions showing the different progenitor–progeny relationships in the neuroglia differentiation. ROC, receiver operating characteristic; TPR, true positive rate; FPR, false positive rate.