Table 2.
Univariate analysis of the correlation between clinicopathological factors and survival of patients with GC
| Parameters | Cumulative Survival Rates, % | Mean Survival Time, month | P value | |
|---|---|---|---|---|
| 3-Year | 5-Year | |||
| Gender | 0.452 | |||
| Male | 63.5 | 47.8 | 47.4 | |
| Female | 64.3 | 60.3 | 49.5 | |
| Age(y) | 0.633 | |||
| <61 | 62.3 | 53.9 | 48.3 | |
| ≥61 | 60.3 | 49.2 | 47 | |
| Tumor diameter (cm) | 0.016 | |||
| <6 | 46.3 | 39 | 39.5 | |
| ≥6 | 67.5 | 57.8 | 51.9 | |
| Location | 0.148 | |||
| Cardia | 62.5 | 46.6 | 47.1 | |
| Corpus | 48.1 | 44.4 | 40.8 | |
| antrum | 66.7 | 66.7 | 54.3 | |
| Depth of invasion | 0.000 | |||
| T1/T2 | 96.2 | 92.3 | 68.2 | |
| T3/T4 | 48 | 40.7 | 42.1 | |
| Histological grade | 0.001 | |||
| Well/moderate | 81.3 | 78 | 62 | |
| Poor/not | 50 | 42.4 | 43 | |
| Lymph node metastasis | 0.000 | |||
| No | 87.8 | 82.9 | 66.8 | |
| Yes | 43.4 | 34.6 | 38.3 | |
| TNM stage | 0.000 | |||
| I-II | 88.5 | 84.6 | 67.1 | |
| III-IV | 36.1 | 27.4 | 33.9 | |
| NEDD4L expression | 0.000 | |||
| negative | 41.8 | 35.6 | 37.7 | |
| positive | 77.2 | 70.2 | 59.1 | |
| HIF1α expression | ||||
| negative | 85.5 | 75.8 | 64.4 | 0.000 |
| positive | 30.6 | 27.2 | 30.8 | |
| NEDD4L/HIF1α expression | 0.000 | |||
| NEDD4L-/HIF1α- | 78.3 | 65.2 | 58.8 | 0.000 |
| NEDD4L+/HIF1α- | 89.7 | 82.1 | 66.5 | |
| NEDD4L-/HIF1α+ | 22.7 | 20.2 | 26.5 | |
| NEDD4L+/HIF1α+ | 50 | 44.4 | 41.4 | |
| NEDD4L+/HIF1α- | 89.7 | 82.1 | 66.5 | 0.000 |
| NEDD4L-/HIF1α+ | 22.7 | 20.2 | 26.5 | |
| NEDD4L-/HIF1α- | 78.3 | 65.2 | 58.8 | 0.070 |
| NEDD4L+/HIF1α+ | 50 | 44.4 | 41.4 | |