Table 3.

Univariate and multivariate analysis of the correlation between clinicopathological factors and prognosis

Variables	Univariate analysis	P value	Multivariate analysis	P value
	HR(95%CI)		HR(95%CI)
Gender (male vs. female)	0.782(0.407-1.503)	0.46		NI
Age (y) (<61 vs. ≥61)	1.128(0.682-1.864)	0.639		NI
Tumor size (cm) (<6 vs. ≥6)	0.544(0.326-0.905)	0.019	1.140(0.670-1.939)	0.63
Histological grade (Poor and other vs Well and moderate)	3.425(1.557-7.535)	0.002	2.715(1.224-6.023)	0.014
Depth of invasion (T3/T4 vs T1/T2)	11.393(2.779-46.7)	0.001	2.674(0.393-18.209)	0.315
Lymph node metastasis (yes vs. no)	5.771(2.619-12.715)	1.37E-05	2.539(0.200-32.213)	0.472
TNM stages ( III/IV vs I/II.)	7.987(3.779-16.880)	5.26E-08	2.282(0.165-31.455)	0.583
NEDD4L expression (+ VS- )	0.354(0.204-0.615)	2.30E-4	0.494(0.279-0.875)	0.016
HIF1αexpression(+ vs -)	5.196(2.913-9.268)	2.38E-8	4.606(2.450-8.661)	2.12E-06
NEDD4L/HIF1α expression (NEDD4L-/HIF1α+ VS NEDD4L+/HIF1α-)	0.121(0.055-0.266)	1.36E-07	0.140(0.059-0.333)	4.42E-07