Table 2.
Mean total body and regional lean mass, muscle cross‐sectional area, and total body fat mass in men with prostate cancer (PCa) treated with androgen deprivation therapy (ADT), PCa controls and healthy controls, and the mean difference between the three groups
| Unadjusted mean ± standard derivation | Unadjusted mean difference (95% confidence interval) | ||||||
|---|---|---|---|---|---|---|---|
| Men treated with ADT | PCa controls | Healthy controls | P value | Men treated with ADT vs. PCa controls | Men treated with ADT vs. healthy controls | PCa controls vs. healthy controls | |
| Lean mass | |||||||
| Total body (kg) | 53.8 ± 6.5 | 54.8 ± 6.3 | 55.5 ± 6.4 | 0.263 | −1.0 (−3.9, 1.8) | −1.8 (−4.4, 0.8) | −0.7 (−3.6, 2.1) |
| Total body (%) | 62.2 ± 6.7 | 67.5 ± 6.0 | 65.9 ± 5.1 | <0.001 | −5.4 (−8.0, −2.7) *** | −3.8 (−6.2, −1.3) ** | 1.6 (−1.0, 4.2) |
| Arm (kg) | 6.2 ± 1.1 | 6.7 ± 0.9 | 6.8 ± 1.0 | 0.006 | −0.4 (−0.9, 0.0) | −0.5 (−0.9, −0.1) ** | −0.1 (−0.6, 0.3) |
| Leg (kg) | 18.5 ± 2.6 | 18.6 ± 2.7 | 19.1 ± 2.6 | 0.362 | −0.1 (−1.3, 1.1) | −0.6 (−1.7, 0.5) | −0.5 (−1.7, 0.7) |
| Appendicular (kg) | 24.7 ± 3.5 | 25.3 ± 3.5 | 25.9 ± 3.5 | 0.164 | −0.5 (−2.1, 1.0) | −1.1 (−2.6, 0.3) | −0.6 (−2.2, 0.9) |
| ALMI (kg/m2) | 8.07 ± 0.95 | 8.13 ± 0.86 | 8.36 ± 0.78 | 0.119 | −0.07 (−0.45, 0.32) | −0.29 (−0.65, 0.06) | −0.23 (−0.61, 0.16) |
| ALMBMI | 0.875 ± 0.117 | 0.961 ± 0.128 | 0.946 ± 0.117 | <0.001 | −0.086 (−0.139, −0.032) *** | −0.071 (−0.120, −0.022) ** | 0.015 (−0.038, 0.068) |
| Muscle cross‐sectional area | |||||||
| Forearm (cm2) | 38.8 ± 5.8 | 41.3 ± 5.2 | 42.2 ± 6.0 | 0.003 | −2.5 (−5.2, 0.1) | −3.5 (−5.9, −1.0) ** | −0.9 (−3.6, 1.8) |
| Forearm (%) | 67.5 ± 6.1 | 73.5 ± 4.5 | 72.7 ± 4.8 | <0.001 | −6.0 (−8.4, −3.5) *** | −5.2 (−7.4, −2.9) *** | 0.8 (−1.7, 3.3) |
| Lower leg (cm2) | 75.4 ± 11.7 | 73.5 ± 9.2 | 76.4 ± 12.1 | 0.403 | 1.8 (−3.3, 7.0) | −1.0 (−5.7, 3.7) | −2.9 (−8.0, 2.3) |
| Lower leg (%) | 73.5 ± 6.8 | 76.4 ± 6.8 | 77.2 ± 6.3 | 0.004 | −3.0 (−6.0, −0.1) * | −3.7 (−6.5, −1.0) ** | −0.8 (−3.9, 2.4) |
| Fat mass | |||||||
| Total body (kg) | 30.5 ± 10.9 | 24.1 ± 8.6 | 26.1 ± 7.5 | <0.001 | 6.4 (2.4, 10.5) ** | 4.4 (0.7, 8.2) * | −2.0 (−6.0, 2.0) |
| Total body (%) | 35.3 ± 7.1 | 29.8 ± 6.4 | 31.5 ± 5.4 | <0.001 | 5.4 (2.6, 8.3) *** | 3.8 (1.2, 6.4) ** | −1.7 (−4.5, 1.1) |
Data are unadjusted mean ± standard deviation and unadjusted mean difference (95% confidence interval). ALM, appendicular lean mass; ALMBMI, appendicular lean mass adjusted for body mass index; ALMI, appendicular lean mass index. Bold = statistical significance.
*
P < 0.05.
**
P < 0.01.
***
P < 0.001.