Figure 3.

Treatment with RK35 antibody reduces collagen deposition in muscles of oculopharyngeal muscular dystrophy mice: Mice were administered with a weekly regimen of either saline or the RK35 antibody (10 mg/kg i.p.) for 10 weeks from 12‐week of age. Five randomly selected whole TA muscle sections from all groups were stained for (A) collagen VI and (B) picosirius red, and five random fields were imaged and analysed for the percentage area of collagen staining. The mice treated with the antibody consistently displayed a reduced collagen deposition, with the area of collagen in the disease model normalized to wild‐type levels. The average area per group is plotted, bars representing standard error of the mean, with P‐values obtained by analysis of variance after a false discovery rate correction (*P < 0.05 and **P < 0.01). TA, tibialis anterior.