Table 1.

Functional Enrichment Analysis of Proteins from Self-Organizing Map Cluster C

Category	Term	Description	Count	FDR	Symbols
Molecular function	GO:0005215	Transporter activity	29	2.43E-10	KCC2, GABRB2, ATP5F1, TTYH1, CACNB4, GC2, TOMM20, TTYH3, SFXN1, CACNG2, PTP, VGAT, GAT3, OSBP, SFXN5, NCX1, MCT1, FATP1, SCN2A, SFXN3, LRP1, LAT1, ATP1A4, ATP1B3, FXYD1, HBZ, NNT, ANT4, GABRA1
Biological process	GO:0055085	Transmembrane support	35	2.23E-14	KCC2, SHANK1, GABRB2, ATP5F1, TTYH1, DPP6, CACNB4, GC2, TSC22D3, RAB8B, TOMM20, PAM16, TTYH3, PPIF, SFXN1, CACNG2, PTP, VGAT, GAT3, CHCHD4, SFXN5, NCX1, MCT1, SCN2A, AFG3L2, SFXN3, LAT1, NLGN2, SAMM50, ATP1A4, ATP1B3, FXYD1, NNT, ANT4, GABRA1
Cellular component	GO:0097458	Neuron part	26	6.08E-07	KCC2, SHANK1, TTYH1, DPP6, SNPH, TPRN, NTRK2, GNG13, CNTNAP1, VTI1A, GABBR2, GRM3, CPNE5, ADAM22, TULP1, VGAT, GAT3, HEPACAM, NCX1, NRXN3, SCN2A, SYNGR3, SYNGR1, LRP1, NLGN2, PCDH9
Mouse phenotype	MP:0002064	Seizures	11	6.02E-05	KCC2, CACNB4, NTRK2, GABBR2, ADAM22, CACNG2, GAT3, AIFM1, SYNGR3, SYNGR1, GABRA1
Disease	C0014544	Epilepsy	10	1.01E-03	KCC2, GABRB2, CACNB4, GRM3, ADAM22, CACNG2, VGAT, GAT3, SCN2A, GABRA1
Pathway	377263	GABAergic synapse	8	6.38E-08	KCC2, GABRB2, GNG13, GNG2, GABBR2, VGAT, GAT3, GABRA1

FDR, false discovery rate; GABA, gamma-aminobutyric acid.