Figure 2.

Relationship of challenge dose to time of fever onset. Time to fever onset is calculated for each subject from temperature listings (as described in the Methods) as the first time point in which the subject exhibited 2 consecutive readings ≥100°F. The data represent the calculated exposure (as described in the methods) to F. tularensis Schu S4 in those subjects exposed to a target exposure = 25,000 cfu.