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. 2019 Oct 22;6:229. doi: 10.3389/fmed.2019.00229

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Copyright © 2019 Williams, Baker, Guina, Hewitt, Lanning, Hill, May, Fogtman and Pittman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship of mean time to adverse event onset to exposure dose. Mean day (± SD) of first reporting of Adverse Events upon challenge with indicated doses of F. tularensis Schu S4. (A) Represents those in the majority or all of subjects, (B) represents AEs present in about half of subjects and (C) those in about 30% of subjects. Number of subjects exposed are indicated with dose, while the number of subjects that had a particular AE are labeled above the respective bars. Fever is calculated in hours and back-calculated to days, while other AEs and antibiotic administration are only reported by day of study. Note that only 50% of subjects exposed to 200 cfu experienced fever. Any of those exposed to 200 cfu that did not get fever, also did not get treated with antibiotic and only one developed antibodies by agglutination microtiter.