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. Author manuscript; available in PMC: 2019 Oct 29.
Published in final edited form as: Nano Lett. 2018 Oct 23;18(11):7021–7029. doi: 10.1021/acs.nanolett.8b02989

Figure 3.

Figure 3.

Myosin undergoes structural changes in the presence of elevated calcium. (a, b) Mouse muscle fibers exposed to calcium results in approximately a 10% increase in the distance between the A bands (data presented are MEAN ± SEM, n = 5). (c) Dose-dependent increase in A band distances (*p < 0.005). (d) Circular dichroism spectroscopy of BC myosin demonstrates unwinding of the α helix (Supporting Information, Table 1S). Calcium concentrations used are 0 mM (black), 5 mM (blue), 10 mM (green), and 15 mM (red). An average of 30 scans were collected in total for each sample from triplicate preparations.