Table 3.

Association between promoter methylation of SHMT1 and baseline characteristics in EH cases

	N	SHMT1 hypomethylation	SHMT1 hypermethylation	OR (95% CI)	P‐value
Case	241	62	179	10.104 (6.769‐15.086)	<0.001
Control	288	224	64
Gender
Male	144	39	105	1.195 (0.659‐2.167)	0.557
Female	97	23	74	1
Age (y)
>65	93	39	54	3.925 (2.141‐7.196)	<0.001
≤65	148	23	125	1
BMI (kg/m2)
>24	110	30	80	1.160 (0.650‐2.069)	0.615
≤24	131	32	99	1
Hcy (mmol/L)
>15	120	40	80	2.250 (1.237‐4.091)	0.007
≤15	121	22	99	1
LDL (mmol/L)
>3.12	110	26	84	1.224 (0.683‐2.195)	0.496
≤3.12	131	36	95	1
Glu (mmol/L)
>6.18	47	15	32	0.682 (0.340‐1.368)	0.352
≤6.18	194	47	147	1

The methylation level of SHMT1 ≥15.67% was considered as hypermethylation and <15.67% was considered as hypomethylation.

BMI, body mass index; EH, essential hypertension; Glu, blood glucose; Hcy, plasma homocysteine; LDL, low‐density lipoprotein.