Regions of Aβ-related atrophy ordered by acceleration and stabilization points. Regions, including the insula, posterior cingulate, amygdala, putamen, and precuneus, show early signs of atrophy before the hippocampus and entorhinal cortex. Parietal regions appear to have a shorter transition compared to temporal lobe regions with respect to Aβ. Red, yellow, and black dots represent significant (P <.05), marginally significant (.10 > P <.05), and nonsignificant (P >.10) acceleration or deceleration, respectively. Scale is pg/mL CSF Aβ42. Abbreviation: CSF, cerebrospinal fluid. Reproduced with permission from [266].