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. Author manuscript; available in PMC: 2019 Oct 29.
Published in final edited form as: Alzheimers Dement. 2017 Mar 22;13(4):e1–e85. doi: 10.1016/j.jalz.2016.11.007

Fig. 22.

Fig. 22.

Longitudinal changes in cognition in subtypes of Aβ+ cognitively normal subjects. Identified subtypes of cognitively normal subjects consisted of those with predominantly hippocampal atrophy, predominantly cortical atrophy, hippocampal and cortical atrophy combined, or neither type of atrophy. Baseline, 1-year, and 2-year follow-up data on (A) MMSE indicating global cognition, (B) ADNI-Mem indicating memory function, and (C) ADNI-EF indicating executive function are plotted, with means and standard errors. Abbreviations: ADNI, Alzheimer’s Disease Neuroimaging Initiative; BI, both impaired; BS, both spared; CA, cortical atrophy only; EF, executive function; HA, hippocampal atrophy only; Mem, memory domain; MMSE, Mini–Mental State Examination. Reproduced with permission from [272].