Skip to main content
. Author manuscript; available in PMC: 2019 Oct 29.
Published in final edited form as: Alzheimers Dement. 2017 Mar 22;13(4):e1–e85. doi: 10.1016/j.jalz.2016.11.007

Fig. 29.

Fig. 29.

Conceptual model linking white-matter hyperintensities to clinical progression of AD. Regional white-matter hyperintensities (WMHs) affect tau directly (a), affect regional atrophy and clinical progression directly (b), and modify the effect of tau on disease progression (c). The interaction between regional WMHs and Aβ has yet to be elucidated. Abbreviation: AD, Alzheimer’s disease. Reproduced with permission from [313].