Fig. 39.

Associations between 249 variables shown by a circular visualization of correlation plot. Data from 928 patients with mild cognitive impairment were used to produce a network visualization of the complex relationships between and within variables in ADNI. Lines represent the Spearman rank correlation coefficient |(r)| = .3 between two variables. 1—sex, 2—years education, 3—age, 4—MMSE, 5—ADAS total score, 6—ADAS modified, 7—CDR composite score, 8—CDR-SOB composite score, 9—FAQ, 10—GDS, 11—Hachinski Ischemic Scale score, 12—NIQ total score, 13—brain volume, 14—intracranial volume, 15—ventricular volume, 16—hippocampal volume, 17—inferior lateral ventricular volume, 18—middle temporal volume, 19—inferior temporal volume, 20—fusiform cortical volume, 21—entorhinal cortex volume, 22—APOE4 carrier, 23—no. of APOE4 alleles, 24—TOMM40 polyT allele one, 25—TOMM40 polyT allele 2, 26—8-Iso-PGF, 27—8,12-iso-IPFa, 28—CSF white blood cell count, 29—CSF red blood cell count, 30—CSF total protein concentration, 31—CSF glucose level, 32—total plasma homocysteine level, 33—plasma Aβ40 level, 34—plasma Aβ42 level, 35—plasma Aβ40:AB42 ratio, 36—CSF Aβ42 level, 37—CSF t-tau level, 39—CSF Aβ42:t-tau ratio, 40—CSF Aβ42-p-tau ratio, 41—CSF p-tau:t-tau ratio, 42 to 115—74 CSF analytes measured by multiplex assay, 116 to 249—hundred and 34 plasma analytes measured by multiplex assay. Abbreviations: ADAS, Alzheimer’s Disease Assessment Scale; ADNI, Alzheimer’s Disease Neuroimaging Initiative; CDR-SOB, Clinical Dementia Rating–Sum of Boxes; CSF, cerebrospinal fluid; FAQ, Functional Activities Questionnaire; MMSE, Mini–Mental State Examination. Reproduced with permission from [425].