Prediction of progression from mild cognitive impairment to Alzheimer’s disease within 3 years. Markers in plasma or CSF predicted progression with a relatively high sensitivity compared to standard AD CSF biomarkers, regional MRI volumes, or cognitive scores. Prediction includes seven models combining different subsets of variables. Correct classification rate of the top 20 variables was estimated on the test data set after 1000-fold resampling of the learning and test data sets. Sex and age were included in all models. APOE4 indicates apolipoprotein ε4. Abbreviations: AD, Alzheimer’s disease; CSF, cerebrospinal fluid; MRI, magnetic resonance imaging. Reproduced with permission from [425].