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CSF ferritin independently predicts brain structural changes. (A–C) Longitudinal hippocampal volumetric changes based on tertiles of CSF: (A) ferritin, (B) ApoE, (C) tau/Aβ42. (D–F) Longitudinal volumetric ventricular changes based on tertiles of CSF: (D) ferritin, (E) ApoE, (F) tau/Aβ42. Abbreviations: CN, cognitively normal; CSF, cerebrospinal fluid; H, highest tertile; M, middle tertile; MCI, mild cognitive impairment. Reproduced with permission from [152].
