Table 1.
Clinical and cognitive characteristics of ADNI-2 subjects
| N | CN, N = 314 | SMC, N = 107 | EMCI, N = 300 | LMCI, N = 311 | AD, N = 150 | Combined, N = 1182 | P-value | |
|---|---|---|---|---|---|---|---|---|
| Age | 1182 | 74.1 (5.8) | 72.2 (5.6) | 71.2 (7.4) | 73.1 (7.4) | 74.7 (8.2) | 73.0 (7.0) | <.00l1 |
| Sex: female | 1182 | 158 (50%) | 62 (58%) | 133 (44%) | 127 (41%) | 62 (41%) | 542 (46%) | .0092 |
| Education (years) | 1182 | 16.5 (2.6) | 16.8 (2.5) | 16.0 (2.7) | 16.1 (2.8) | 15.8 (2.7) | 16.2 (2.7) | .0071 |
| Marital | 1182 | |||||||
| Married | 226 (72%) | 70 (65%) | 227 (76%) | 242 (78%) | 130 (87%) | 895 (76%) | <.0012 | |
| Widowed | 42 (13%) | 15 (14%) | 21 (7%) | 38 (12%) | 14 (9%) | 130 (11%) | ||
| Divorced | 33 (11%) | 12 (11%) | 34 (11%) | 26 (8%) | 5 (3%) | 110 (9%) | ||
| Never married | 13 (4%) | 10 (9%) | 14 (5%) | 3 (1%) | 1 (1%) | 41 (3%) | ||
| Unknown | 0 (0%) | 0 (0%) | 4 (1%) | 2 (1%) | 0 (0%) | 6 (1%) | ||
| Ethnicity | 1182 | |||||||
| Not Hisp/Latino | 300 (96%) | 103 (96%) | 284 (95%) | 304 (98%) | 141 (94%) | 1132 (96%) | ||
| Hisp/Latino | 13 (4%) | 2 (2%) | 15 (5%) | 7 (2%) | 8 (5%) | 45 (4%) | ||
| Unknown | 1 (0%) | 2 (2%) | 1 (0%) | 0 (0%) | 1 (1%) | 5 (9%) | .142 | |
| Race | 1182 | |||||||
| Am Indian/Alaskan | 1 (0%) | 0 (0%) | 1 (0%) | 0 (0%) | 0 (0%) | 2 (0%) | ||
| Asian | 7 (2%) | 0 (0%) | 4 (1%) | 5 (2%) | 5 (3%) | 21 (2%) | .0492 | |
| Hawaiian/Other PI | 0 (0%) | 0 (0%) | 1 (0%) | 1 (0%) | 0 (0%) | 2 (0%) | ||
| Black | 21 (7%) | 3 (3%) | 5 (2%) | 10 (3%) | 6 (4%) | 45 (4%) | ||
| White | 283 (90%) | 101 (94%) | 279 (93%) | 294 (95%) | 137 (91%) | 1094 (93%) | ||
| More than one | 2 (1%) | 3 (3%) | 7 (2%) | 1 (0%) | 2 (1%) | 15 (1%) | ||
| Unknown | 0 (0%) | 0 (0%) | 3 (1%) | 0 (0%) | 0 (0%) | 3 (0%) | ||
| CDR-SB | 1182 | 0.030 (0.126) | 0.075 (0.179) | 1.286 (0.757) | 1.630 (0.910) | 4.507 (1.696) | 1.341 (1.622) | <.00l1 |
| ADAS-11 | 1178 | 5.8 (3.0) | 5.6 (2.7) | 7.9 (3.5) | 11.1 (4.6) | 20.8 (7.1) | 9.6 (6.4) | <.00l1 |
| MMSE | 1182 | 29.1 (1.2) | 29.0 (1.2) | 28.4 (1.6) | 27.5 (1.8) | 23.1 (2.1) | 27.7 (2.4) | <.00l1 |
Abbreviations: ADNI, Alzheimer’s Disease Neuroimaging Initiative; CN, cognitively normal; SMC, subjective memory concern; EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment; AD, Alzheimer’s disease; CDR-SB, Clinical Dementia Rating–Sum of Boxes; ADAS-11, Alzheimer’s Disease Assessment Scale, 11 point; MMSE, Mini–Mental State Examination; SD, standard deviation.
NOTE. Mean (SD) for continuous variables. N is the number of nonmissing values. Tests used:
1
F test;
2
Pearson test.