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. Author manuscript; available in PMC: 2019 Oct 29.
Published in final edited form as: Ann Integr Mol Med. 2019 Aug 25;1(1):48–60.

Figure 6: RNA-dependent RNA polymerase can transcribe the cap “G” of mRNA.

Figure 6:

Data shown is adapted from Figure 1, top panel. Uppercase letters – nucleotide sequence of the sense strand; lowercase letters – nucleotide sequence of the antisense strand. “u” highlighted in blue – 3′-terminal nucleotide of the antisense strand corresponding to the transcription start site of mRNA; “uC” highlighted in blue –the projected junction structure in the absence of the cap “G” transcription. “c” highlighted in green – transcript of the cap”G”; “ucC” highlighted in green – the resulting junction structure when cap “G” is transcribed. A: Projected self-priming configuration of the antisense strand in the absence of the cap “G” transcription. B: Projected nucleotide sequence of the sense/antisense junction in the absence of the cap “G” transcription. C: Detected nucleotide sequence of the sense/ antisense junction. D: Self-priming configuration of the antisense strand as defined by experimental results. Note that the genomic sequence upstream of the TSS cannot account for the additional 3′-terminal “C” in the antisense strand.