Table 4. The correlation between the DNA methylation and expression patterns of the candidate genes in blastocysts of different groups.
| Expression = E | After_4C | After_16C | All_stages | Until_4C | Until_16C | BM + EGF | BM + HA | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Methylation = M | E | M | E | M | E | M | E | M | E | M | E | M | E | M | |
| COL1A2 | Promoter | ↑ | ↑ | ↓ | ↑ | ↑ | ↓ | ↑ | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ |
| Distal Promoter | ↑ | ↑ | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | |
| COL4A1 | Promoter | ↑ | ↑ | ↓ | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ─ |
| Distal Promoter | ↑ | ↓ | ↓ | ↓ | ↑ | ↑ | ↓ | ↑ | ↑ | ↓ | ↑ | ↓ | ↑ | ↓ | |
| RAC1 | Promoter | ─ | ─ | ─ | ↑ | ↑ | ↑ | ↑ | ↑ | ─ | ─ | ─ | ↑ | ↑ | ↑ |
| Intron | ─ | ─ | ─ | ─ | ↑ | ↑ | ↑ | ↑ | ─ | ↑ | ─ | ↓ | ↑ | ─ | |
Symbols ↑ and↓ indicate up and downregulation of gene expression, respectively while ↑ and ↓ indicate the hypermethylation and hypomethylation of the gene, respectively.