Fig 5. Model for the role of therapy-induced senescence in tumorigenesis.

Senescence accumulated after chemotherapy/Radiotherapy leads to suppression of cancer and premature aging. As therapy-recipients age, the impact on the suppression gradually goes down, whereas the impact on aging gradually goes up. After reaching certain point, age-related cancer incidence rises in the long-term cancer survivors. Time point of our study and potential period for the intervention of senolytic drugs in order to reduce cancer incidence are indicated in the graph.