Table 1. Histopathology of Tg26 and Tg26 x APOL1 dual transgenic mice.

	Tg26 (n = 21)	P	Tg26+G0 (n = 21)	P	Tg26+G2 (n = 18)	P
# scored glomeruli per animal, mean	201		230		210
Segmental sclerotic, % of total glomeruli	9.9%	ref	6.6%	NS	10.9%	NS
Global sclerotic, % of total glomeruli	3.7%	ref	3.8%	NS	5.2%	NS
Segmental collapse, % of total glomeruli	0%	ref	0%	NS	0%	NS
Global collapse, % of total glomeruli	0%	ref	0.4%	NS	0%	NS
Glomerular hyperplasia, any	6.0%	ref	6.0%	NS	1.5%	NS
Podocyte hypertrophy, any	10.0%	ref	16.0% *	NS	1.5%	NS
Tubular microcysts, mean±SD scored on 0–4 scale	0.88 ± 1.27	ref	0.90 ± 1.47	NS	0.89 ± 1.33	NS
Tubular atrophy, mean±SD scored on 0–4 scale	0.07 ± 0.24	ref	0.05 ± 0.22	NS	0 ± 0	NS
Interstitial fibrosis, mean±SD scored on 0–4 scale	0.05 ± 0.22	ref	0.20 ± 0.52	NS	0.17 ± 0.51	NS
Interstitial inflammation, mean±SD scored on 0–4 scale	0.93 ± 1.29	ref	1.26 ± 1.66	NS	1.08 ± 1.41	NS

NS, not significant compared to Tg26. * P = 0.03 compared to Tg26+G2.