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. 2019 Sep 26;39(11):2338–2352. doi: 10.1161/ATVBAHA.119.313246

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© 2019 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Histological quantification of coronary plaque classification and components. A, Quantification of the frequency of occurrence of the different plaque types. Data are presented as a percentage of the total number of segments, separately for the mildly diseased pigs (MDs; 283 3 mm segments) and advanced-diseased pigs (AD) pigs (297 3 mm-segments). *z-score >1.96 compared with ADs. Bottom of the figure: example images of the respective plaque types: no plaque and intimal thickening: HE-staining; other plaque types: Oil-red-O staining (red=lipids and purple=calcifications). B, Mean (±SD) percentage of 3 mm segments per artery that contained the respective plaque component in ADs (black bars) and MDs (white bars). *P<0.05. C–F, Histological examples of the plaque components quantified in the bar graph. C, Neovascularisation (*, CD31-staining: brown), (D) magnification of (C). E, Intraplaque hemorrhage (†, HE-staining). F, Lipids (Oil-red-O staining: red), microcalcifications (arrowhead), and macrocalcifications (arrows). G, Mean (±SD) area percentage per artery of the respective plaque component in ADs (black bars) and MDs (white bars) in segments positive for that plaque component. *P<0.05 compared with ADs. H–K, Example images of: (H) lipids (Oil-red-O staining; red); (I) macrophages (CD68 staining: brown); (J) collagen (Miller staining: purple). The Miller staining was used to delineate the necrotic core (indicated in yellow in [K]).